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I'm with Cyrem on this one. Give it the original UI and leave a new UI to mods. Better idea: make your revised UI a mod. You'll be more inclined to make your hooks and whatever more usable because you'll end up making it with the same tools everyone else has access to. You can even bundle the GUI mod with the base download if you wanted.

My personal preference would be to keep it as true to the original game as possible whilst making sure everything is modifiable as possible. That way if people do want a new UI, (among other things) it's just a matter of making some changes to the remake.

Ah, the ol' Westwood-style RTS. Tiberian Sun was my favorite! And the Rock Raiders should be glad their Energy Crystals aren't Tiberium crystals I like moddable GUIs. Unfortunately, GUIs are one of the least moddable parts of most games. Probably because they mix data (usually moddable) with code (usually not moddable, unless there's scripts), and it takes some effort to get that separated out. Idk if modern Unity has this too, but some engines like Godot allow loading GUIs from data files containing the Button/Image/TextBox/whatever objects with their positions, sizes, event function names, and other variables. That's just a lot more work than implementing the GUI inside the engine. Maybe not worth it for a simple game?

I could add an option to have two GUI's, the one from the original LRR and the Reloaded version so people can choose between which layout they want. Command & Conquer series (Generals was an exception to that rule), Emperor: Battle for Dune, 8Bit Armies among others that have top right minimaps, although I do play other games that have the minimap on a different locations but those have a different GUI than I am working on currently.