Dear, I'm gratefull for the patches.
For anyone who has no idea how to, this is how I did it. I have no knowledge of PC's or programming so I have no idea what I did, but it worked.
Step 1: download the game from exemple 'myabandondedware'
Step 2: open with winrar
Step 3: Execute the 'setup.exe' file
Step 4: Download & install HxD
Step 5: open the lego island 2 exe file with HxD. you will get a file that looks chinese, but it is a 'excel-kinda-like structure'. Each row gives you the 'offset' and the column is the last number of the offset.
Step 6: search the correct line: 8420 and look at column C & D. There you will find 0F 85 (stated here above by mumboking) and change it to EB 48.
Step 7: repeat for the 8478 as stated above
Step 8: the game should now start whitout the CD.
Thanks to Iran for the patches.